BIOGRAPHICAL SKETCH

NAME Campbell, Kevin Peter	POSITION TITLE Professor of Physiology and Biophysics; Neurology Investigator, Howard Hughes Medical Institute
INSTITUTION AND LOCATION	DEGREE (if applicable)	YEAR(s)	FIELD OF STUDY
Manhattan College, Bronx, NY	B.S.	1973	Physics
University of Rochester, Rochester, NY	M.S.	1976	Biophysics
University of Rochester, Rochester, NY	Ph.D.	1979	Biophysics
University of Toronto, Toronto, Canada	Postdoc	1979-1981	Membrane Biochemistry

Positions and Employment

1973-1977 Graduate Student, Department of Radiation Biology and Biophysics, University of Rochester

1977, 1978 Teaching Assistant, Graduate Biochemistry, University of Rochester

1979-1981 Postdoctoral Fellow with Dr. David MacLennan, University of Toronto

1981-1985 Assistant Professor, Dept. of Physiology and Biophysics, University of Iowa

1985-1988 Associate Professor, Dept. of Physiology and Biophysics, University of Iowa

1988- Professor, Dept. of Physiology and Biophysics, University of Iowa

1989- Investigator, Howard Hughes Medical Institute

1997- Professor, Dept. of Neurology, University of Iowa

1999- Roy J. Carver Chair, Department of Physiology and Biophysics, University of Iowa

2002- Interim Head, Department of Physiology and Biophysics, University of Iowa

1988-2001 Editorial Board: Journal of Biological Chemistry

1989-1995 Muscular Dystrophy Association Fellowship Review Committee

1991-1995 Physiology Study Section Member, National Institutes of Health

1996- Muscular Dystrophy Association Scientific Advisory Committee

2000-2004 Editorial Board: Journal of Cell Biology

2001-2005         Skeletal Muscle Biology and Exercise Physiology Study Section, National Institutes of Health

2004- Member, National Academy of Sciences

Honors

1973 Phi Beta Kappa, Manhattan College

1977-1978 Elon Huntington Hooker Fellow, University of Rochester

1978-1981 Medical Research Council Postdoctoral Fellowship, University of Toronto

1984-1989 Established Investigator of the American Heart Association

1989 University of Iowa Foundation Distinguished Professor of Physiology and Biophysics

1990 Regent's Award for Faculty Excellence

1992 Emilio Trabucchi Foundation Medal

1993 Muscular Dystrophy Association Service Merchandise Leadership Award

1994 ASBMB-Amgen Award

1994 International Albrecht Fleckenstein Award

1995 INSERM/Académie des Sciences Prix

1996 American Academy of Neurology Decade of the Brain Award

1997 Duchenne-Erb-Preis Award (German Muscular Dystrophy Association)

1999 Fellow of the Biophysical Society

1999 Roy J. Carver Chair in Physiology and Biophysics

1999 Elected to the National Academy of Medicine (formerly Institute of Medicine) , National Academy of Sciences

2000 G. Conte Prize for Basic Research, Mediterranean Society of Myology

2001 S. Mouchly Small, MDA Scientific Achievement Award

2001 Elsevier Science Award at the World Muscle Society Meeting (2001)

2003 University of Manitoba Samuel Weiner Distinguished Visitor Award (2003)

2004 Rochester Distinguished Scholar Medal

2004 American Academy of Neurology Lecturer Award

2004 Elected to the National Academy of Sciences

Selected peer-reviewed publications (from 433 publications).

Campbell, K.P. and Kahl, S.D. Association of Dystrophin and an Integral Membrane Glycoprotein. Nature 338:259-262, 1989.

Ervasti, J.M., Ohlendieck, K., Kahl, S.D., Gaver, M.G., and Campbell, K.P. Deficiency of a Glycoprotein Component of the Dystrophin Complex in Dystrophic Muscle. Nature 345:315-319, 1990.

Ervasti, J.M. and Campbell, K.P. Membrane Organization of the Dystrophin-Glycoprotein Complex. Cell 66:1121-1131, 1991.

Ibraghimov-Beskrovnaya, O., Ervasti, J.M., Leveille, C.J., Slaughter, C.A., Sernett, S.W., and Campbell, K.P. Primary Structure of Dystrophin-Associated Glycoproteins Linking Dystrophin to the Extracellular Matrix. Nature 355:696-702, 1992.

Matsumura, K., Tomé, F.M.S., Collin, H., Azibi, K., Chaouch, M., Kaplan, J.-C., Fardeau, M., and Campbell, K.P. Deficiency of the 50K Dystrophin-Associated Glycoprotein in Severe Childhood Autosomal Recessive Muscular Dystrophy. Nature 359:320-322, 1992.

Matsumura, K., Ervasti, J.M., Ohlendieck, K., Kahl, S.D., and Campbell, K.P. Association of Dystrophin-Related Protein With Dystrophin-Associated Proteins in mdx Mouse Muscle. Nature 360:588-591, 1992.

Ervasti, J.M. and Campbell, K.P. A Role for the Dystrophin-Glycoprotein Complex as a Transmembrane Linker Between laminin and Actin. J. Cell Biol. 122:809-823, 1993.

Roberds, S.L., Leturcq, F., Allamand, V., Piccolo, F., Jeanpierre, M., Anderson, R.D., Lim, L.E., Lee, J.C., Tomé, F.M.S., Romero, N.B., Fardeau, M., Beckmann, J.S., Kaplan, J.-C., and Campbell, K.P. Missense Mutations in the Adhalin Gene Linked to Autosomal Recessive Muscular Dystrophy. Cell 78: 625-633, 1994.

Campbell, K.P. Three Muscular Dystrophies: Loss of Cytoskeleton-Extracellular Matrix Linkage. Cell 80: 675-679, 1995.

Henry, M.D. and Campbell, K.P. A Role for Dystroglycan in Basement Membrane Assembly. Cell 95: 859-870, 1998.

Holt, K.H., Lim, L.E., Straub, V., Venzke, D.P., Duclos, F., Anderson, R.D., Davidson, B.L., and Campbell, K.P. Functional Rescue of the Sarcoglycan Complex in the BIO 14.6 Hamster Using δ-Sarcoglycan Gene Transfer. Mol. Cell 1:841-848, 1998.

Coral-Vazquez, R., Cohn, R.D., Moore, S.A., Hill, J.A., Weiss, R.M., Davisson, R., Straub, V., Barresi, R., Bansal, D., Hrstka, R.F., Sudig, P., Faulkner, J.A., Williamson, R. and Campbell, K.P. Disruption of the Sarcoglycan-Sarcospan Complex in Vascular Smooth Muscle: A Novel Mechanism in the Pathogenesis of Cardiomyopathy and Muscular Dystrophy. Cell. 98:465-474, 1999.

Durbeej, M., Cohn, R.D., Hrstka, R.F., Moore, S.A., Allamand, V., Davidson, B.L. Williamson, R.A. and Campbell, K.P. Disruption of the β-Sarcoglycan Gene Reveals Pathogenetic Complexity of Limb-Girdle Muscular Dystrophy Type 2E. Mol. Cell. 5: 141-151, 2000.

Michele, D.E., Barresi, R., Kanagawa, M., Saito, F., Cohn, R.D., Satz, J.S., Dollar, J., Nishino, I., Kelley, R.I., Somer, H., Straub, V., Mathews, K.D., Moore, S.A. and Campbell, K.P. Post-translational Disruption of Dystroglycan-Ligand Interactions in Congenital Muscular Dystrophies. Nature 418: 417-422, 2002.

Moore, S.A., Saito, F., Chen, J., Michele, D.E., Henry, M., Messing, A., Cohn, R.D., Barta, S.R., Westra, S., Williamson, R., Hoshi, T., Campbell, K.P. Deletion of Brain Dystroglycan Recapitulates Aspects of Congenital Muscular Dystrophy Nature 418: 422-425, 2002.

Cohn, R.D., Henry, M.D., Michele, D.E., Barresi, R., Saito, F., Moore, S.A., Flanagan, J.D., Skwarchuk, M.W., Robbins, M.E., Williamson, R., Campbell, K.P. Disruption of Dag1 in Differentiated Skeletal Muscle Reveals a Role for Dystroglycan in Muscle Regeneration. Cell 110: 639-648, 2002.

Bansal, D., Miyake, K., Vogel, S.S., Groh, S., Chen, C-C., Williamson, R., McNeil, P.L., Campbell, K.P. Defective Membrane Repair in Dysferlin-Deficient Muscular Dystrophy. Nature 423: 168-172, 2003.

Saito, F., Moore, S.A., Barresi, R., Henry, M.D., Messing, A., Ross-Barta, S.E., Cohn, R.D., Williamson, R.A., Sluka, K.A., Sherman, D.L., Brophy, P.J., Schmelzer, J.D., Low, P.A., Wrabetz, L., Fletri, M.L., Campbell, K.P. Unique Role of Dystroglycan in Peripheral Nerve Myelination, Nodal Structure, and Sodium Channel Stabilization. Neuron. 38(5): 747-758, 2003.

Durbeej, M., Sawatzki, S.M., Barresi, R., Schmainda, K.M., Allamand, V., Michele, D.E., and Campbell, K. P. Gene Transfer Etablishes Primacy of Striated Versus Smooth Muscle Sarcoglycan Complex in Limb-Girdle Muscular Dystrophy. Proc. Natl. Acad. Sci. 100(15): 8910-8915, 2003.

Sampaolesi, M., Torrente, I., Innocenzi, A., Tonlorenzi, R., D’Antona, G., Pellegrino, M.A., Barresi, R., Bresolin, N., Cusella de Angelis, M.G., Campbell, K.P., Bottinelli, R. and Cossu, G. Cell Therapy of Alpha Sarcoglycan Null Dystrophic Mice Through Intra-arterial Delivery of Mesoangioblasts. Science. 301(5632): 487-492, 2003.

Chen, C.C., Lamping, K.G., Nuno, D.B., Barresi, R., Prouty, S.J., Lavoie, J.L., Cribbs, L.L., England, S.K., Sigmund, C.D., Weiss, R.M., Williamson, R.A., Hill, J.A., and Campbell, K.P. Abnormal Coronary Function in Mice Deficient in α_1H T-type Ca²⁺ Channels. Science 302(5649): 1416-1418, 2003.

Barresi, R., Michele, D.E., Kanagawa, M., Harper, H.A., Dovico, S.A., Satz, J.S., Moore, S.A., Zhang, W., Schachter, H., Dumanski, J.P., Cohn, R.D., Nishino, I. and Campbell K.P. LARGE Can Functionally Bypass-Dystroglycan Glycosylation Defects in Distinct Congenital Muscular Dystrophies. Nat. Med. 10(7): 696-703, 2004.

Kanagawa, M., Saito, F., Kunz, S., Yoshida-Moriguchi, T., Barresi, R., Kobayashi, Y.M., Muschler, J., Dumanski, J.P., Michele, D.E, Oldstone, M.B. and Campbell, K.P. Molecular Recognition by LARGE is Essential for Expression of Functional Dystroglycan. Cell 117(7): 953-964, 2004.

Singh, J., Itahana, Y., Knight-Krajewski, S., Kanagawa, M., Campbell, K.P., Bissell, M.J. and Muschler, J. Proteolytic Enzymes and Altered Glycosylation Modulate Dystroglycan Function in Carcinoma Cells. Cancer Res 64(17): 6152-6159, 2004.

Kobayashi, Y.M., Rader, E.P., Crawford, R.W., Iyengar, N.K., Thedens, D.R., Faulkner, J.A., Parikh, S.V., Weiss, R.M., Chamberlain, J.S., Moore, S.A., Campbell, K.P. Sarcolemma-Localized nNOS is Required to Maintain Activity After Mild Exercise. Nature. 456:511-5, 2008.

Yoshida-Moriguchi, T., Yu, L., Stalnaker, S.H., Davis, S., Kunz, S., Oldstone, M.B.A., Schachter, H., Wells, L. and Campbell, K.P. O-Mannosyl Phosphorylation of Alpha-Dystroglycan is Required for Laminin Binding.  Science 327:88-92, 2010.

Hara, Y., Balci, B., Kanagawa, M., Beltran-Valero de Bernabe, D., Gundesli, H., Yoshida-Moriguchi, T., Willer, T., Satz, J.S., Burden, S.J., Oldstone, M.B.A., Accardi, A., Talim, B., Muntoni, F., Topaloglu, H., Dincer, P. and Campbell, K.P.  A Dystroglycan Missense Mutation Associated with Mild Muscular Dystrophy and Cognitive Impairment. N. Eng. J. Med. 364: 939-46, 2011.

Hara, Y., Kanagawa, M., Kunz, S., Yoshida-Moriguchi, T., Satz, J.S., Kobayashi, Y.M., Zhu, Z., Burden, S.J., Oldstone, M.B.A., Campbell, K.P. LARGE-dependent Modification of Dystroglycan at Thr-317-319 is Required for Laminin Binding and Arenavirus Infection. Proc. Natl. Acad. Sci. USA. 108: 17426-31, 2011.

Inamori, K., Yoshida-Moriguchi, T., Hara, Y., Anderson, M.E., Yu, L. and Campbell, K.P.  Dystroglycan Function Requires Xylosyl- and Glucuronyltransferase Activities of LARGE.  Science 335: 93-96, 2012.

Willer, T., Lee, H., Lommel, M., Yoshida-Moriguchi, T., Beltran Valero de Bernabe, D., Venzke, D., Cirak, S., Schachter, H., Vajsar, J., Voit, T., Muntoni, F., Loder, A.S., Dobyns, W.B., Winder, T.L., Strahl, S., Mathews, K.D., Nelson, S.F., Moore, S.A., and Campbell, K.P. ISPD loss-of-function mutations reveal novel pathogenetic mechanism responsible for impaired dystroglycan O-mannosylation that causes Walker-Warburg syndrome. Nat. Genet. 44: 575-80, 2012.

Yoshida-Moriguchi, T., Willer, T., Anderson, ME, Venzke, D., Whyte, T., Muntoni, F., Lee, H., Nelson, SF, Yu, L., Campbell, KP. SGK196 is a Glycosylation-Specific O-Mannose Kinase Required for Dystroglycan Function. Science 341: 896-9, 2013.

Goddeeris, M.M., Wu, B., Venzke, D., Yoshida-Moriguchi, T., Saito, F., Matsumura, K., Moore, S.A., Campbell, K.P. Large glycans on dystroglycan function as a tunable matrix scaffold to prevent dystrophy. Nature 503: 136-40, 2013.

Willer, T., Inamori, K., Venzke, D., Harvey, C.D., Morgensen, G., Hara, Y., Beltrán Valero de Bernabé, D., Yu, L., Wright, K.M., Campbell, K.P. The glucuronyltransferase B4GAT1 is required for initiation of LARGE-mediated α-dystroglycan functional glycosylation. eLife 3;3, 2014.