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Research interests are directed toward the autonomic dysregulation of the circulation which occurs in pathologic states such as hypertension and heart failure. Specific studies examine the cellular and molecular mechanisms of mechanical activation of baroreceptor neurons and chemical activation of chemoreceptors. Sensory transductions by ion channels are explored in KO and transgenic mice and in models of hypertension and heart failure. Integrated control of sympathetic activity during sleep apnea and hypertension has been the focus of studies in humans. Dr. Abboud is the Edith King Chair of Cardiovascular Research. He directs an interdisciplinary cardiovascular research training program, now in its 33rd year, and a Program Project Grant on Integrative Functions in Neurovascular Control, which at 37 years and counting is the longest-running PPG with the same PI. He has been director of the Cardiovascular Research Center since 1974.
1. Abboud FM, Lu YJ, and Chapleau MW: Molecular Components of Neural Sensory Transduction: DEG/ENaC proteins in baro and chemoreceptors. In: Molecular Sensors for Cardiovascular Homeostasis, Wang, Donna H. (Ed.). New York, NY: Springer, publisher, pp. 51-74, 2007. 2. Snitsarev V, Whiteis CA, Chapleau MW, and Abboud FM: Mechano- and chemosensitivity of rat nodose neurones – selective excitatory effects of prostacyclin. J Physiol, 582:1:177-194, 2007. 3. Tan ZY, Lu Y, Whiteis CA, Benson CJ, Chapleau MW, and Abboud FM: Acid-Sensing Ion Channels Contribute to Transduction of Extracellular Acidosis in Rat Carotid Body Glomus Cells. Cir. Res, 101: 1009-1019, 2007. 4. Yermolaieva Petroff E, Price MP, Snitsarev V, Gong H, Korovkina V, Abboud FM, Welsh M.: Acid Sensing Ion Channels Interact with and Inhibit BK K+ Channels. PNAS, 3140-3144, 2008.
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