Mark E. Anderson, M.D., Ph.D.
        Professor and Head, Department of Internal Medicine
        Professor of Molecular Physiology & Biophysics

Office: Phone: Email:

SE308 GH (319) 356-2746 mark-e-anderson@uiowa.edu

Research Interests

Dr. Anderson's clinical interests center around treatment of patients with cardiac arrhythmias. His research interests lie in understanding the biology behind heart failure, cardiac arrhythmias and sudden death. The ultimate goal of this research is to develop new therapies for heart failure and arrhythmias. His research focuses on a signaling protein called calmodulin kinase II and the role it plays in heart rhythm abnormalities, heart muscle enlargement and dysfunction.

Selected Publications

Rong Zhang, Michelle S.C. Khoo, Yuejin Wu, Igor Dzhura, Gemin Ni, Tatiana A. Vishnivetskaya, Chad Grueter, Ernest C. Madu, Vsevolod V. Gurevich, Roger J. Colbran, ME Anderson. Calmodulin kinase II inhibition protects against structural heart disease. Nature Medicine 2005, 11:409-417.

2. rueter CE, Abiria SA, Dzhura I, Wu Y, Hamm A-J, Mohler PJ, Anderson ME, Colbran RJ. Molecular basis for facilitation of native Ca2+ channels by CaMKII. Mol Cell 2006; 23:641-650.

3. Erickson JR, Joiner MA, Guan X, Kutschke W, Yang J, Oddis CV, Bartlett RK, Lowe JS, O’Donnell S, Aykin-Burns N, Zimmerman MC, Zimmerman K, Ham A-JL, Weiss RM, Spitz DR, Shea MA, Colbran RJ, Mohler PJ, Anderson ME. Direct oxidation results in Ca2+ independent activation of CaMKII. Cell 2008; 133:462-474.

4. Thiel WH, Chen B, Hund TJ, Koval OM, Purohit AP, Song LS, Mohler PJ, Anderson ME. Proarrhythmic defects in a ventricular myocyte model of Timothy Syndrome require calmodulin kinase II. Circulation 2008 in press.