The application of molecular techniques to the analysis of physiological processes has revolutionized the ability of basic scientists to derive mechanistic explanations for phenomena previously limited to mere observational descriptions. Members of the Department have pioneered many aspects of the modern use of molecular approaches in physiological research during the past decade by wedding molecular biology with traditional techniques such as electrophysiology and other forms of cellular analysis.

In the area of Cell and Molecular Biology, studies by several investigators are underway to analyze the molecular mechanisms of tissue- and cell-specific transcription during development and in response to various physiologic stimuli such as oxidative stress. Several research programs in the department are directed toward understanding how intracellular protein sorting is mediated by the formation, targeting and fusion of specialized transport vesicles. This work involves the study of organelle biogenesis, intracellular processing and sorting of proteins, as well as secretion of neurotransmitters and other signaling molecules in both yeast and mammalian systems. This common theme along with intersecting aspects of other more diverse medically related questions have formed collaborative links between members of this group providing the conceptual and intellectual interactions necessary for continual rapid progress.

Cell and Molecular Biology Faculty