Kevin
P. Campbell
Investigator, Howard Hughes Medical Institute
Roy J. Carver Professor of Physiology & Biophysics and Neurology
Dr. Campbell is an Investigator for the Howard Hughes Medical Institute and a Professor of Physiology and Biophysics at the University of Iowa, Roy J. and Lucille A. Carver College of Medicine, Iowa City. He recieved his B.S. degree in physics from Manhattan College, his master's degree from the University of Rochester School of Medicine and Dentistry, and his Ph.D. in Biophysics from the Department of Radiation Biology and Biophysics at the University of Rochester. He did postdoctoral studies in the laboratory of Dr. David MacLennan at the Banting and Best Department of Medical Research, University of Toronto, before moving to Iowa in 1981.
Name
Campbell, Kevin P.
kevin-campbell@uiowa.edu
Professor of Physiology and Biophysics
Neurology Investigator, Howard Hughes Medical Institute
Manhattan College, Bronx, NY
University of Rochester, Rochester, NY
University of Rochester, Rochester, NY
University of Toronto, Toronto, Canada
B.S.
M.S.
Ph.D.
Postdoc
1973
1976
1976
1979-1981
Physics
Biophysics
Biophysics
Membrane Biochemistry
Professional Experience:
1973-1977 Graduate Student, Department of Radiation Biology and Biophysics,
University of Rochester
1977, 1978 Teaching Assistant, Graduate Biochemistry, University of Rochester
1979-1981 Postdoctoral Fellow with Dr. David MacLennan, University of Toronto
1981-1985 Assistant Professor, Dept. of Physiology and Biophysics, University of Iowa
1985-1988 Associate Professor, Dept. of Physiology and Biophysics, University of Iowa
1988- Professor, Dept. of Physiology and Biophysics, University of Iowa
1989- Investigator, Howard Hughes Medical Institute
1997- Professor, Dept. of Neurology, University of Iowa
1999- Roy J. Carver Chair, Department of Physiology and Biophysics,
University of Iowa
2002- Interim Head, Department of Physiology and Biophysics, University of Iowa
1988-1993 Editorial Board: Journal of Biological Chemistry
1989-1995 Muscular Dystrophy Association Fellowship Review Committee
1991-1995 Physiology Study Section Member, National Institutes of Health
1996-2002 Editorial Board: Journal of Biological Chemistry
1996- Muscular Dystrophy Association Scientific Advisory Committee
2000- Editorial Board: Journal of Cell Biology
2001- Skeletal Muscle Biology and Exercise Physiology Study Section, National
Institutes of Health
2004- Member, National Academy of SciencesHonors and Awards:
1973 Phi Beta Kappa, Manhattan College 1977-1978 Elon Huntington Hooker Fellow, University of Rochester 1978-1981 Medical Research Council Postdoctoral Fellowship, University of Toronto 1984-1989 Established Investigator of the American Heart Association 1989 University of Iowa Foundation Distinguished Professor of Physiology and
Biophysics 1990 Regent's Award for Faculty Excellence 1992 Emilio Trabucchi Foundation Medal 1993 Muscular Dystrophy Association Service Merchandise Leadership Award 1994 ASBMB-Amgen Award 1994 International Albrecht Fleckenstein Award 1995 INSERM/Académie des Sciences Prix 1996 American Academy of Neurology Decade of the Brain Award 1997 Duchenne-Erb-Preis Award (German Muscular Dystrophy Association) 1999 Fellow of the Biophysical Society 1999 Roy J. Carver Chair in Physiology and Biophysics 1999 Elected to the Institute of Medicine, National Academy of Sciences 2000 G. Conte Prize for Basic Research, Mediterranean Society of Myology 2001 S. Mouchly Small, MDA Scientific Achievement Award
2001 Elsevier Science Award at the World Muscle Society Meeting
2003 University of Manitoba Samuel Weiner Distruished Visitor Award
2004 Rochester Distinguished Scholar Medal
2004 American Academy of Neurology Lecturer Award
2004 Elected to the National Academy of Sciences
Publications (24 out of 329 total publications):
Campbell, K.P. and Kahl, S.D. Association of Dystrophin and an Integral Membrane Glycoprotein. Nature 338:259-262, 1989.
Ervasti, J.M., Ohlendieck, K., Kahl, S.D., Gaver, M.G., and Campbell, K.P. Deficiency of a Glycoprotein Component of the Dystrophin Complex in Dystrophic Muscle. Nature 345:315-319, 1990.
Ervasti, J.M. and Campbell, K.P. Membrane Organization of the Dystrophin-Glycoprotein Complex. Cell 66:1121-1131, 1991.
Ibraghimov-Beskrovnaya, O., Ervasti, J.M., Leveille, C.J., Slaughter, C.A., Sernett, S.W., and Campbell, K.P. Primary Structure of Dystrophin-Associated Glycoproteins Linking Dystrophin to the Extracellular Matrix. Nature 355:696-702, 1992.
Matsumura, K., Tomé, F.M.S., Collin, H., Azibi, K., Chaouch, M., Kaplan, J.-C., Fardeau, M., and Campbell, K.P. Deficiency of the 50K Dystrophin-Associated Glycoprotein in Severe Childhood Autosomal Recessive Muscular Dystrophy. Nature 359:320-322, 1992.
Matsumura, K., Ervasti, J.M., Ohlendieck, K., Kahl, S.D., and Campbell, K.P. Association of Dystrophin-Related Protein With Dystrophin-Associated Proteins in mdx Mouse Muscle. Nature 360:588-591, 1992.
Ervasti, J.M. and Campbell, K.P. A Role for the Dystrophin-Glycoprotein Complex as a Transmembrane Linker Between laminin and Actin. J. Cell Biol. 122:809-823, 1993.
Roberds, S.L., Leturcq, F., Allamand, V., Piccolo, F., Jeanpierre, M., Anderson, R.D., Lim, L.E., Lee, J.C., Tomé, F.M.S., Romero, N.B., Fardeau, M., Beckmann, J.S., Kaplan, J.-C., and Campbell, K.P. Missense Mutations in the Adhalin Gene Linked to Autosomal Recessive Muscular Dystrophy. Cell 78: 625-633, 1994.
Campbell, K.P. Three Muscular Dystrophies: Loss of Cytoskeleton-Extracellular Matrix Linkage. Cell 80: 675-679, 1995.
Henry, M.D. and Campbell, K.P. A Role for Dystroglycan in Basement Membrane Assembly. Cell 95: 859-870, 1998.
Holt, K.H., Lim, L.E., Straub, V., Venzke, D.P., Duclos, F., Anderson, R.D., Davidson, B.L., and Campbell, K.P. Functional Rescue of the Sarcoglycan Complex in the BIO 14.6 Hamster Using d-Sarcoglycan Gene Transfer. Mol. Cell 1:841-848, 1998.
Coral-Vazquez, R., Cohn, R.D., Moore, S.A., Hill, J.A., Weiss, R.M., Davisson, R., Straub, V., Barresi, R., Bansal, D., Hrstka, R.F., Sudig, P., Faulkner, J.A., Williamson, R. and Campbell, K.P. Disruption of the Sarcoglycan-Sarcospan Complex in Vascular Smooth Muscle: A Novel Mechanism in the Pathogenesis of Cardiomyopathy and Muscular Dystrophy. Cell. 98:465-474, 1999.
Durbeej, M., Cohn, R.D., Hrstka, R.F., Moore, S.A., Allamand, V., Davidson, B.L. Williamson, R.A. and Campbell, K.P. Disruption of the ß-Sarcoglycan Gene Reveals Pathogenetic Complexity of Limb-Girdle Muscular Dystrophy Type 2E. Mol. Cell. 5: 141-151, 2000.
Michele, D.E., Barresi, R., Kanagawa, M., Saito, F., Cohn, R.D., Satz, J.S., Dollar, J., Nishino, I., Kelley, R.I., Somer, H., Straub, V., Mathews, K.D., Moore, S.A. and Campbell, K.P. Post-translational Disruption of Dystroglycan-Ligand Interactions in Congenital Muscular Dystrophies. Nature 418: 417-422, 2002.
Moore, S.A., Saito, F., Chen, J., Michele, D.E., Henry, M., Messing, A., Cohn, R.D., Barta, S.R., Westra, S., Williamson, R., Hoshi, T., Campbell, K.P. Deletion of Brain Dystroglycan Recapitulates Aspects of Congenital Muscular Dystrophy Nature 418: 422-425, 2002.
Cohn, R.D., Henry, M.D., Michele, D.E., Barresi, R., Saito, F., Moore, S.A., Flanagan, J.D., Skwarchuk, M.W., Robbins, M.E., Williamson, R., Campbell, K.P. Disruption of Dag1 in Differentiated Skeletal Muscle Reveals a Role for Dystroglycan in Muscle Regeneration. Cell 110: 639-648, 2002.
Bansal, D., Miyake, K., Vogel, S.S., Groh, S., Chen, C-C., Williamson, R., McNeil, P.L., Campbell, K.P. Defective Membrane Repair in Dysferlin-Deficient Muscular Dystrophy. Nature 423: 168-172, 2003.
Saito, F., Moore, S.A., Barresi, R., Henry, M.D., Messing, A., Ross-Barta, S.E., Cohn, R.D., Williamson, R.A., Sluka, K.A., Sherman, D.L., Brophy, P.J., Schmelzer, J.D., Low, P.A., Wrabetz, L., Fletri, M.L., Campbell, K.P. Unique Role of Dystroglycan in Peripheral Nerve Myelination, Nodal Structure, and Sodium Channel Stabilization. Neuron. 38(5): 747-758, 2003.
Durbeej, M., Sawatzki, S.M., Barresi, R., Schmainda, K.M., Allamand, V., Michele, D.E., and Campbell, K. P. Gene Transfer Etablishes Primacy of Striated Versus Smooth Muscle Sarcoglycan Complex in Limb-Girdle Muscular Dystrophy. Proc. Natl. Acad. Sci. 100(15): 8910-8915, 2003.
Sampaolesi, M., Torrente, I., Innocenzi, A., Tonlorenzi, R., D’Antona, G., Pellegrino, M.A., Barresi, R., Bresolin, N., Cusella de Angelis, M.G., Campbell, K.P., Bottinelli, R. and Cossu, G. Cell Therapy of Alpha Sarcoglycan Null Dystrophic Mice Through Intra-arterial Delivery of Mesoangioblasts. Science. 301(5632): 487-492, 2003.
Chen, C.C., Lamping, K.G., Nuno, D.B., Barresi, R., Prouty, S.J., Lavoie, J.L., Cribbs, L.L., England, S.K., Sigmund, C.D., Weiss, R.M., Williamson, R.A., Hill, J.A., and Campbell, K.P. Abnormal Coronary Function in Mice Deficient in a1H T-type Ca2+ Channels. Science 302(5649): 1416-1418, 2003.
Barresi, R., Michele, D.E., Kanagawa, M., Harper, H.A., Dovico, S.A., Satz, J.S., Moore, S.A., Zhang, W., Schachter, H., Dumanski, J.P., Cohn, R.D., Nishino, I. and Campbell K.P. LARGE Can Functionally Bypass-Dystroglycan Glycosylation Defects in Distinct Congenital Muscular Dystrophies. Nat. Med. 10(7): 696-703, 2004.
Kanagawa, M., Saito, F., Kunz, S., Yoshida-Moriguchi, T., Barresi, R., Kobayashi, Y.M., Muschler, J., Dumanski, J.P., Michele, D.E, Oldstone, M.B. and Campbell, K.P. Molecular Recognition by LARGE is Essential for Expression of Functional Dystroglycan. Cell 117(7): 953-964, 2004.
Singh, J., Itahana, Y., Knight-Krajewski, S., Kanagawa, M., Campbell, K.P., Bissell, M.J. and Muschler, J. Proteolytic Enzymes and Altered Glycosylation Modulate Dystroglycan Function in Carcinoma Cells. Cancer Res 64(17): 6152-6159, 2004.