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Kevin Campbell
  


Kevin P. Campbell, Ph.D.

kevin-campbell@uiowa.edu
  Investigator, Howard Hughes Medical Institute
Chair and Department Executive Officer, Department of Molecular Physiology and Biophysics
Roy J. Carver Biomedical Research Chair

 

Dr. Campbell is an Investigator for the Howard Hughes Medical Institute and a Professor of Molecular Physiology and Biophysics at the University of Iowa, Roy J. and Lucille A. Carver College of Medicine, Iowa City. He recieved his B.S. degree in physics from Manhattan College, his master's degree from the University of Rochester School of Medicine and Dentistry, and his Ph.D. in Biophysics from the Department of Radiation Biology and Biophysics at the University of Rochester. He did postdoctoral studies in the laboratory of Dr. David MacLennan at the Banting and Best Department of Medical Research, University of Toronto, before moving to Iowa in 1981.

Dr. Campbell's current HHMI research.

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Dr. Campbell's Biosketch (printable version)

 

EDUCATION/TRAINING
INSTITUTION AND LOCATION
DEGREE
YEAR
FIELD OF STUDY
Manhattan College, Bronx, NY
B.S.
1973
 Physics
University of Rochester, Rochester, NY
M.S.
1976
 Biophysics
University of Rochester, Rochester, NY
Ph.D.
1976
 Biophysics
University of Toronto, Toronto, Canada
Postdoc
1979-1981
 Membrane Biochemistry
           
PROFESSIONAL EXPERIENCE
1973-1977 Graduate Student, Department of Radiation Biology and Biophysics, University of Rochester
1977, 1978 Teaching Assistant, Graduate Biochemistry, University of Rochester
1979-1981 Postdoctoral Fellow with Dr. David MacLennan, University of Toronto
1981-1985 Assistant Professor, Dept. of Physiology and Biophysics, University of Iowa
1985-1988 Associate Professor, Dept. of Physiology and Biophysics, University of Iowa
1988- Professor, Dept. of Physiology and Biophysics, University of Iowa
1989- Investigator, Howard Hughes Medical Institute
1997- Professor, Dept. of Neurology, University of Iowa
1999- Roy J. Carver Chair, Department of Physiology and Biophysics, University of Iowa
2002- Interim Head, Department of Physiology and Biophysics, University of Iowa
1988-1993 Editorial Board: Journal of Biological Chemistry
1989-1995 Muscular Dystrophy Association Fellowship Review Committee
1991-1995 Physiology Study Section Member, National Institutes of Health
1996-2002 Editorial Board: Journal of Biological Chemistry
1996- Muscular Dystrophy Association Scientific Advisory Committee
2000-2004 Editorial Board: Journal of Cell Biology
2001-2005 Skeletal Muscle Biology and Exercise Physiology Study Section, National Institutes of Health
2002-2005 Interim Department Chair, Department of Molecular Physiology and Biophysics, University of Iowa
2004- Member, National Academy of Sciences
2005- Chair and Executive Department Officer, Department of Molecular Physiology and Biophysics, University of Iowa
2005- Professor, Department of Internal Medicine, University of Iowa
2005-2009 Council Member, National Arthritis and Musculoskeletal and Skin Disease Advisory Council
2006- Board Member, Duke NUS-Graduate Medical School Singapore, Scientific Advisory Board
2008- University of Iowa Animal Care Facilities Planning Taskforce
   

 

HONORS AND AWARDS
1973 Phi Beta Kappa, Manhattan College
1977-1978 Elon Huntington Hooker Fellow, University of Rochester
1978-1981 Medical Research Council Postdoctoral Fellowship, University of Toronto
1984-1989 Established Investigator of the American Heart Association
1989 University of Iowa Foundation Distinguished Professor of Physiology and Biophysics
1990 Regent's Award for Faculty Excellence
1992 Emilio Trabucchi Foundation Medal
1993 Muscular Dystrophy Association Service Merchandise Leadership Award
1994 ASBMB-Amgen Award
1994 International Albrecht Fleckenstein Award
1995 INSERM/Académie des Sciences Prix
1996 American Academy of Neurology Decade of the Brain Award
1997 Duchenne-Erb-Preis Award (German Muscular Dystrophy Association)
1999 Fellow of the Biophysical Society
1999 Roy J. Carver Chair in Physiology and Biophysics
1999 Elected to the National Academy of Medicine (formerly Institute of Medicine), National Academy of Sciences
2000 G. Conte Prize for Basic Research, Mediterranean Society of Myology
2001 S. Mouchly Small, MDA Scientific Achievement Award
2001 Elsevier Science Award at the World Muscle Society Meeting
2003 University of Manitoba Samuel Weiner Distruished Visitor Award
2004 Rochester Distinguished Scholar Medal
2004 American Academy of Neurology Lecturer Award
2004 Elected to the National Academy of Sciences
2005 Carver College of Medicine Distinguished Mentor Award
2006 American Academy of Arts and Sciences
2007 Presidential Lecturer, The University of Iowa
2009 March of Dimes Prize in Developmental Biology
2010 A. Ross McIntyre Award
 

 

PUBLICATIONS (30 out of 443 total publications):
Campbell, K.P. and Kahl, S.D. Association of Dystrophin and an Integral Membrane Glycoprotein. Nature 338:259-262, 1989. [PDF]
Ervasti, J.M., Ohlendieck, K., Kahl, S.D., Gaver, M.G., and Campbell, K.P. Deficiency of a Glycoprotein Component of the Dystrophin Complex in Dystrophic Muscle. Nature 345:315-319, 1990. [PDF]
Ervasti, J.M. and Campbell, K.P. Membrane Organization of the Dystrophin-Glycoprotein Complex. Cell 66:1121-1131, 1991. [PDF]
Ibraghimov-Beskrovnaya, O., Ervasti, J.M., Leveille, C.J., Slaughter, C.A., Sernett, S.W., and Campbell, K.P. Primary Structure of Dystrophin-Associated Glycoproteins Linking Dystrophin to the Extracellular Matrix. Nature 355:696-702, 1992. [PDF]
Matsumura, K., Tomé, F.M.S., Collin, H., Azibi, K., Chaouch, M., Kaplan, J.-C., Fardeau, M., and Campbell, K.P. Deficiency of the 50K Dystrophin-Associated Glycoprotein in Severe Childhood Autosomal Recessive Muscular Dystrophy. Nature 359:320-322, 1992. [PDF]
Matsumura, K., Ervasti, J.M., Ohlendieck, K., Kahl, S.D., and Campbell, K.P. Association of Dystrophin-Related Protein With Dystrophin-Associated Proteins in mdx Mouse Muscle. Nature 360:588-591, 1992. [PDF]
Ervasti, J.M. and Campbell, K.P. A Role for the Dystrophin-Glycoprotein Complex as a Transmembrane Linker Between laminin and Actin. J. Cell Biol. 122:809-823, 1993. [PDF]
Roberds, S.L., Leturcq, F., Allamand, V., Piccolo, F., Jeanpierre, M., Anderson, R.D., Lim, L.E., Lee, J.C., Tomé, F.M.S., Romero, N.B., Fardeau, M., Beckmann, J.S., Kaplan, J.-C., and Campbell, K.P. Missense Mutations in the Adhalin Gene Linked to Autosomal Recessive Muscular Dystrophy. Cell 78: 625-633, 1994. [PDF]
Campbell, K.P. Three Muscular Dystrophies: Loss of Cytoskeleton-Extracellular Matrix Linkage. Cell 80: 675-679, 1995. [PDF]
Henry, M.D. and Campbell, K.P. A Role for Dystroglycan in Basement Membrane Assembly. Cell 95: 859-870, 1998. [PDF]
Holt, K.H., Lim, L.E., Straub, V., Venzke, D.P., Duclos, F., Anderson, R.D., Davidson, B.L., and Campbell, K.P. Functional Rescue of the Sarcoglycan Complex in the BIO 14.6 Hamster Using d-Sarcoglycan Gene Transfer. Mol. Cell 1:841-848, 1998. [PDF]
Coral-Vazquez, R., Cohn, R.D., Moore, S.A., Hill, J.A., Weiss, R.M., Davisson, R., Straub, V., Barresi, R., Bansal, D., Hrstka, R.F., Sudig, P., Faulkner, J.A., Williamson, R. and Campbell, K.P. Disruption of the Sarcoglycan-Sarcospan Complex in Vascular Smooth Muscle: A Novel Mechanism in the Pathogenesis of Cardiomyopathy and Muscular Dystrophy. Cell. 98:465-474, 1999. [PDF]
Durbeej, M., Cohn, R.D., Hrstka, R.F., Moore, S.A., Allamand, V., Davidson, B.L. Williamson, R.A. and Campbell, K.P. Disruption of the ß-Sarcoglycan Gene Reveals Pathogenetic Complexity of Limb-Girdle Muscular Dystrophy Type 2E. Mol. Cell. 5: 141-151, 2000. [PDF]

Michele, D.E., Barresi, R., Kanagawa, M., Saito, F., Cohn, R.D., Satz, J.S., Dollar, J., Nishino, I., Kelley, R.I., Somer, H., Straub, V., Mathews, K.D., Moore, S.A. and Campbell, K.P. Post-translational Disruption of Dystroglycan-Ligand Interactions in Congenital Muscular Dystrophies. Nature 418: 417-422, 2002. [PDF]
Moore, S.A., Saito, F., Chen, J., Michele, D.E., Henry, M., Messing, A., Cohn, R.D., Barta, S.R., Westra, S., Williamson, R., Hoshi, T., Campbell, K.P. Deletion of Brain Dystroglycan Recapitulates Aspects of Congenital Muscular Dystrophy. Nature 418: 422-425, 2002. [PDF]
Cohn, R.D., Henry, M.D., Michele, D.E., Barresi, R., Saito, F., Moore, S.A., Flanagan, J.D., Skwarchuk, M.W., Robbins, M.E., Williamson, R., Campbell, K.P. Disruption of Dag1 in Differentiated Skeletal Muscle Reveals a Role for Dystroglycan in Muscle Regeneration. Cell 110: 639-648, 2002. [PDF]
Bansal, D., Miyake, K., Vogel, S.S., Groh, S., Chen, C-C., Williamson, R., McNeil, P.L., Campbell, K.P. Defective Membrane Repair in Dysferlin-Deficient Muscular Dystrophy. Nature 423: 168-172, 2003. [PDF]
Saito, F., Moore, S.A., Barresi, R., Henry, M.D., Messing, A., Ross-Barta, S.E., Cohn, R.D., Williamson, R.A., Sluka, K.A., Sherman, D.L., Brophy, P.J., Schmelzer, J.D., Low, P.A., Wrabetz, L., Fletri, M.L., Campbell, K.P. Unique Role of Dystroglycan in Peripheral Nerve Myelination, Nodal Structure, and Sodium Channel Stabilization. Neuron. 38(5): 747-758, 2003. [PDF]
Durbeej, M., Sawatzki, S.M., Barresi, R., Schmainda, K.M., Allamand, V., Michele, D.E., and Campbell, K. P. Gene Transfer Etablishes Primacy of Striated Versus Smooth Muscle Sarcoglycan Complex in Limb-Girdle Muscular Dystrophy. Proc. Natl. Acad. Sci. 100(15): 8910-8915, 2003. [PDF]
Sampaolesi, M., Torrente, I., Innocenzi, A., Tonlorenzi, R., D’Antona, G., Pellegrino, M.A., Barresi, R., Bresolin, N., Cusella de Angelis, M.G., Campbell, K.P., Bottinelli, R. and Cossu, G. Cell Therapy of Alpha Sarcoglycan Null Dystrophic Mice Through Intra-arterial Delivery of Mesoangioblasts. Science 301(5632): 487-492, 2003. [PDF]
Chen, C.C., Lamping, K.G., Nuno, D.B., Barresi, R., Prouty, S.J., Lavoie, J.L., Cribbs, L.L., England, S.K., Sigmund, C.D., Weiss, R.M., Williamson, R.A., Hill, J.A., and Campbell, K.P. Abnormal Coronary Function in Mice Deficient in a1H T-type Ca2+ Channels. Science 302(5649): 1416-1418, 2003. [PDF]
Barresi, R., Michele, D.E., Kanagawa, M., Harper, H.A., Dovico, S.A., Satz, J.S., Moore, S.A., Zhang, W., Schachter, H., Dumanski, J.P., Cohn, R.D., Nishino, I. and Campbell K.P. LARGE Can Functionally Bypass alpha-Dystroglycan Glycosylation Defects in Distinct Congenital Muscular Dystrophies. Nat. Med. 10(7): 696-703, 2004. [PDF]
Kanagawa, M., Saito, F., Kunz, S., Yoshida-Moriguchi, T., Barresi, R., Kobayashi, Y.M., Muschler, J., Dumanski, J.P., Michele, D.E, Oldstone, M.B. and Campbell, K.P. Molecular Recognition by LARGE is Essential for Expression of Functional Dystroglycan. Cell 117(7): 953-964, 2004. [PDF]
Singh, J., Itahana, Y., Knight-Krajewski, S., Kanagawa, M., Campbell, K.P., Bissell, M.J. and Muschler, J. Proteolytic Enzymes and Altered Glycosylation Modulate Dystroglycan Function in Carcinoma Cells. Cancer Res 64(17): 6152-6159, 2004. [PDF]
Kobayashi, Y.M., Rader, E.P., Crawford, R.W., Iyengar, N.K., Thedens, D.R., Faulkner, J.A., Parikh, S.V., Weiss, R.M., Chamberlain, J.S., Moore, S.A., Campbell, K.P. Sarcolemma-Localized nNOS is Required to Maintain Activity After Mild Exercise. Nature. 456: 511-5, 2008. [PDF]
Yoshida-Moriguchi, T., Yu, L., Stalnaker, S.H., Davis, S., Kunz, S., Oldstone, M.B.A., Schachter, H., Wells, L. and Campbell, K.P.  O-Mannosyl Phosphorylation of Alpha-Dystroglycan is Required for Laminin Binding.  Science 327:88-92, 2010. [PDF]
Hara, Y., Balci, B., Kanagawa, M., Beltran-Valero de Bernabe, D., Gundesli, H., Yoshida-Moriguchi, T., Willer, T., Satz, J.S., Burden, S.J., Oldstone, M.B.A., Accardi, A., Talim, B., Muntoni, F., Topaloglu, H., Dincer, P. and Campbell, K.P.  A Dystroglycan Mutation Associated with Limb-Girdle Muscular Dystrophy and Cognitive Impairment. N. Eng. J. Med. 364: 939-46, 2011. [PDF]
Hara, Y., Kanagawa, M., Kunz, S., Yoshida-Moriguchi, T., Satz, J.S., Kobayashi, Y.M., Zhu, Z., Burden, S.J., Oldstone, M.B.A., Campbell, K.P. Like-acetylglucosaminyltransferase (LARGE)-dependent Modification of Dystroglycan at Thr-317/319 is Required for Laminin Binding and Arenavirus Infection. Proc. Natl. Acad. Sci. USA. 108: 17426-31, 2011. [PDF]
Inamori, K., Yoshida-Moriguchi, T., Hara, Y., Anderson, M.E., Yu, L. and Campbell, K.P.  Dystroglycan Function Requires Xylosyl- and Glucuronyltransferase Activities of LARGE.  Science 335: 93-96, 2012. [PDF]
Willer, T., Lee, H., Lommel, M., Yoshida-Moriguchi, T., Beltran Valero de Bernabe, D., Venzke, D., Cirak, S., Schachter, H., Vajsar, J., Voit, T., Muntoni, F., Loder, A.S., Dobyns, W.B., Winder, T.L., Strahl, S., Mathews, K.D., Nelson, S.F., Moore, S.A., and Campbell, K.P. ISPD loss-of-function mutations reveal novel pathogenetic mechanism responsible for impaired dystroglycan O-mannosylation that causes Walker-Warburg syndrome. Nat. Genet. 44: 575-80, 2012. [PDF]
Yoshida-Moriguchi, T., Willer, T., Anderson, ME, Venzke, D., Whyte, T., Muntoni, F., Lee, H., Nelson, SF, Yu, L., Campbell, KP. SGK196 is a Glycosylation-Specific O-Mannose Kinase Required for Dystroglycan Function. Science 341: 896-9, 2013. [PDF]
Goddeeris, M.M., Wu, B., Venzke, D., Yoshida-Moriguchi, T., Saito, F., Matsumura, K., Moore, S.A., Campbell, K.P. Large glycans on dystroglycan function as a tunable matrix scaffold to prevent dystrophy. Nature 503: 136-40, 2013. [PDF]

 

  

Campbell Laboratory; 285 Newton Road, 4283 Carver Biomedical Research Building, Iowa City, IA 52242