Primary Focus

           Our research focuses on the molecular mechanisms of photoransduction in rod and cone photoreceptor cells. We are particularly interested in understanding structure-function and signaling mechanisms of the visual G protein transducin and effector enzyme cGMP-phosphodiesterase 6 (PDE6).

Click on the image below to see key steps in the phototransduction cascade.

The movie below shows rods of transgenic Xenopus laevis expressing EGFP-fusion protein of human cone PDE6C.